May 19th, 2022: Total Synthesis through the Lens of Informatics by Ryan Shenvi
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▪️ One of the reasons we work on natural products is that they occupy the areas of chemical space that are difficult to access.
▪️ One of the important aspects of natural product synthesis is that they're complex.
▪️ One of the mysteries in the literature that caught our attention was a compound called GB18.
▪️ One of the things that all the syntheses have in common, which inspired us, is that all of them include a high oxidation state of PXN by alkenes.
▪️ One of the reasons we decided not to go for that route is that it would require an intermediate that is difficult to get hold of.
▪️ One of the key features of this new variant is that it's much more transmissible than the previous ones.
▪️ One of the major benefits of this method is that it uses well-established machanisms.
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