It's normal for this reaction not to react sometimes, I'm certain that will be able to deal with screening conditions.
The compound's biological detection is abnormal. It's better to check if the structure is correct.
The condition of this step looks abnormal, have you searched the database for this type of reaction.
The purity of this intermediate was a bit low, it is normal because it is difficult to purify it by normal phase. I am confident that we can get pure intermediate in the next step.
This kind of structure is unstable, which is normal, the familiar problems are happened before.
It is abnormal that you can't deliver this high priority target on time. What kind of issue you suffer?