For this expensive starting material,one option is to buy it from the vendor. The other option is to make it by ourselves.
We still have some issues about this challenging target. One option is to propose an alternative route to replace the original one. Another is to postpone it until we find a good method to resolve the issues.
For this issue target, one suggestion is screening more conditions, another is to use the alternative route, the other is replace it by another structure.
In order to improve work efficiency, one way is to search literature to find similar chemical reactions before starting the reaction. Another is to screen enough reaction conditions at once to find the best condition in a short time. The third is to prepare a backup route. Once there is a problem with the original route, the backup route can be used as soon as possible.
One option is to do it by ourselves, another opinion is to reach out to experienced staff, and the third option is to postpone a step that we find a right person hired.